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KMID : 0377819880080040456
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Diagnosis and Treatment
1988 Volume.8 No. 4 p.456 ~ p.459
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ATRIAL ANTRIURETIC PEPTIDE IN HYPOTHYROIDISM
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Abstract
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The effect of hypothyroidism on circulating levels of atrial natriuretic peptide (ANP) was studied in 11 hypothyroid patients(aged 11-65yr ; mean, 31yr) and 13 normal subjects(aged 28-39yr ; mean, 32yr). Plasma ANP was 32±9(±SD) pg/ml in normal subjects and 20±5pg/ml in the hypothyroid patig!nts(P＜0.005). In 7 hypothyroid patients, plasma ANP levels were :measured after 10-14 weeks of L-T₄ therapy. ANP increased from 22±5 to 46±18pg/ml(P＜ 0.02), along with an increase in mean serum T₄ from 0.6±0.5 to 8.1±2.5㎍/dl(P＜0.001). Thus, hypothyroidism is characterized by decreased circulating levels of ANP which are reversed by _(L)-T₄ therapy.(J Clin Endocrinol Metab 64:353, 1987)
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KEYWORD
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